The Red Devils pulled level when Antony notched his third goal in as many Premier League games and then Ronaldo completed the turnaround just before half-time.
The five-time Ballon d’Or winner slotted past Jordan Pickford with his left foot for a record-breaking goal.
Ronaldo scored five goals for boyhood club Sporting CP and has racked up 144 for United over two spells. He conquered Italian football with 101 strikes for Juventus and is also Real Madrid’s record goalscorer with 450.
The numbers are just frightening from Ronaldo, who is in his own league when it comes to club goals.